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GLT-1 Loss Accelerates Cognitive Deficit Onset in an Alzheimer's Disease Animal Model

Glutamate transporters regulate normal synaptic network interactions and prevent neurotoxicity by rapidly clearing extracellular glutamate. GLT-1, the dominant glutamate transporter in the cerebral cortex and hippocampus, is significantly reduced in Alzheimer's disease (AD). However, the role G...

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Detalhes bibliográficos
Main Authors: Mookherjee, Paramita, Green, Pattie S., Watson, G. Stennis, Marques, Marcos A., Tanaka, Kohichi, Meeker, Kole D., Meabon, James S., Li, Ning, Zhu, Ping, Olson, Valerie G., Cook, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256092/
https://ncbi.nlm.nih.gov/pubmed/21677376
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3233/JAD-2011-110503
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