Amyloid-β(1–42) Slows Clearance of Synaptically Released Glutamate by Mislocalizing Astrocytic GLT-1

GLT-1, the major glutamate transporter in the adult brain, is abundantly expressed in astrocytic processes enveloping synapses. By limiting glutamate escape into the surrounding neuropil, GLT-1 preserves the spatial specificity of synaptic signaling. Here we show that the amyloid-β peptide Aβ(1–42)...

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Detalhes bibliográficos
Main Authors: Scimemi, Annalisa, Meabon, James S., Woltjer, Randall L., Sullivan, Jane M., Diamond, Jeffrey S., Cook, David G.
Formato: Artigo
Idioma:Inglês
Publicado em: Society for Neuroscience 2013
Assuntos:
Brief Communications
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3866500/
https://ncbi.nlm.nih.gov/pubmed/23516295
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.5274-12.2013
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