Virologic Escape during Danoprevir (ITMN-191/RG7227) Monotherapy Is Hepatitis C Virus Subtype Dependent and Associated with R155K Substitution

Danoprevir is a hepatitis C virus (HCV) NS3/4A protease inhibitor that promotes multi-log(10) reductions in HCV RNA when administered as a 14-day monotherapy to patients with genotype 1 chronic HCV. Of these patients, 14/37 experienced a continuous decline in HCV RNA, 13/37 a plateau, and 10/37 a re...

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Detalhes bibliográficos
Main Authors: Lim, Sharlene R., Qin, Xiaoli, Susser, Simone, Nicholas, John B., Lange, Christian, Herrmann, Eva, Hong, Jin, Arfsten, Ann, Hooi, Lisa, Bradford, Williamson, Nájera, Isabel, Smith, Patrick, Zeuzem, Stefan, Kossen, Karl, Sarrazin, Christophe, Seiwert, Scott D.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2012
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3256012/
https://ncbi.nlm.nih.gov/pubmed/22064535
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.05636-11
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