Preclinical Characteristics of the Hepatitis C Virus NS3/4A Protease Inhibitor ITMN-191 (R7227)

Future treatments for chronic hepatitis C virus (HCV) infection are likely to include agents that target viral components directly. Here, the preclinical characteristics of ITMN-191, a peptidomimetic inhibitor of the NS3/4A protease of HCV, are described. ITMN-191 inhibited a reference genotype 1 NS...

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Detalhes bibliográficos
Main Authors: Seiwert, Scott D., Andrews, Steven W., Jiang, Yutong, Serebryany, Vladimir, Tan, Hua, Kossen, Karl, Rajagopalan, P. T. Ravi, Misialek, Shawn, Stevens, Sarah K., Stoycheva, Antitsa, Hong, Jin, Lim, Sharlene R., Qin, Xiaoli, Rieger, Robert, Condroski, Kevin R., Zhang, Hailong, Do, Mary Geck, Lemieux, Christine, Hingorani, Gary P., Hartley, Dylan P., Josey, John A., Pan, Lin, Beigelman, Leonid, Blatt, Lawrence M.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology (ASM) 2008
Assuntos:
Antiviral Agents
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2592891/
https://ncbi.nlm.nih.gov/pubmed/18824605
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00699-08
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