HIV-Specific CD4 T Cell Responses to Different Viral Proteins Have Discordant Associations with Viral Load and Clinical Outcome

A successful prophylactic vaccine is characterized by long-lived immunity, which is critically dependent on CD4 T cell-mediated helper signals. Indeed, most licensed vaccines induce antigen-specific CD4 T cell responses, in addition to high-affinity antibodies. However, despite the important role of...

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Bibliographische Detailangaben
Hauptverfasser: Ranasinghe, Srinika, Flanders, Michael, Cutler, Sam, Soghoian, Damien Z., Ghebremichael, Musie, Davis, Isaiah, Lindqvist, Madelene, Pereyra, Florencia, Walker, Bruce D., Heckerman, David, Streeck, Hendrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2012
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255877/
https://ncbi.nlm.nih.gov/pubmed/22031937
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05577-11
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