HIV-1-Specific Interleukin-21(+) CD4(+) T Cell Responses Contribute to Durable Viral Control through the Modulation of HIV-Specific CD8(+) T Cell Function

Functional defects in cytotoxic CD8(+) T cell responses arise in chronic human viral infections, but the mechanisms involved are not well understood. In mice, CD4 cell-mediated interleukin-21 (IL-21) production is necessary for the maintenance of CD8(+) T cell function and control of persistent vira...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Hauptverfasser: Chevalier, Mathieu F., Jülg, Boris, Pyo, Augustine, Flanders, Michael, Ranasinghe, Srinika, Soghoian, Damien Z., Kwon, Douglas S., Rychert, Jenna, Lian, Jeffrey, Muller, Matthias I., Cutler, Sam, McAndrew, Elizabeth, Jessen, Heiko, Pereyra, Florencia, Rosenberg, Eric S., Altfeld, Marcus, Walker, Bruce D., Streeck, Hendrik
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology (ASM) 2011
Schlagworte:
Pathogenesis and Immunity
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3020027/
https://ncbi.nlm.nih.gov/pubmed/21047960
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.02030-10
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!

Ähnliche Einträge