Mutations of Gln64 in the HIV-1 gp41 N-Terminal Heptad Repeat Render Viruses Resistant to Peptide HIV Fusion Inhibitors Targeting the gp41 Pocket

To prove that the peptidic HIV-1 fusion inhibitors containing the pocket-binding domain (PBD) mainly target the hydrophobic pocket in the gp41 N-terminal heptad repeat (NHR), we constructed pseudoviruses by replacement of Q64 in the gp41 pocket region with Ala (Q64A) or Leu (Q64L). These viruses wer...

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Hlavní autoři: Yu, Xiaowen, Lu, Lu, Cai, Lifeng, Tong, Pei, Tan, Suiyi, Zou, Peng, Meng, Fanxia, Chen, Ying-hua, Jiang, Shibo
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Microbiology 2012
Témata:
Vaccines and Antiviral Agents
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255876/
https://ncbi.nlm.nih.gov/pubmed/22013063
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05066-11
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