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Mutations at the Base of the Icosahedral Five-Fold Cylinders of Minute Virus of Mice Induce 3′-to-5′ Genome Uncoating and Critically Impair Entry Functions

The linear single-stranded DNA genome of minute virus of mice can be ejected, in a 3′-to-5′ direction, via a cation-linked uncoating reaction that leaves the 5′ end of the DNA firmly complexed with its otherwise intact protein capsid. Here we compare the phenotypes of four mutants, L172T, V40A, N149...

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Autors principals: Cotmore, Susan F., Tattersall, Peter
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255873/
https://ncbi.nlm.nih.gov/pubmed/22013064
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.06119-11
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