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Δγ(1)34.5 Herpes Simplex Viruses Encoding Human Cytomegalovirus IRS1 or TRS1 Induce Interferon Regulatory Factor 3 Phosphorylation and an Interferon-Stimulated Gene Response

The chimeric herpes simplex viruses (HSV) are Δγ(1)34.5 vectors encoding the human cytomegalovirus (HCMV) IRS1 or TRS1 genes. They are capable of late viral protein synthesis and are superior to Δγ(1)34.5 HSVs in oncolytic activity. The interferon (IFN) response limits efficient HSV gene expression...

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Bibliografski detalji
Glavni autori: Cassady, Kevin A., Saunders, Ute, Shimamura, Masako
Format: Artigo
Jezik:Inglês
Izdano: American Society for Microbiology 2012
Teme:
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255867/
https://ncbi.nlm.nih.gov/pubmed/22072777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05099-11
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