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Δγ(1)34.5 Herpes Simplex Viruses Encoding Human Cytomegalovirus IRS1 or TRS1 Induce Interferon Regulatory Factor 3 Phosphorylation and an Interferon-Stimulated Gene Response
The chimeric herpes simplex viruses (HSV) are Δγ(1)34.5 vectors encoding the human cytomegalovirus (HCMV) IRS1 or TRS1 genes. They are capable of late viral protein synthesis and are superior to Δγ(1)34.5 HSVs in oncolytic activity. The interferon (IFN) response limits efficient HSV gene expression...
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| Auteurs principaux: | , , |
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| Format: | Artigo |
| Langue: | Inglês |
| Publié: |
American Society for Microbiology
2012
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| Sujets: | |
| Accès en ligne: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3255867/ https://ncbi.nlm.nih.gov/pubmed/22072777 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05099-11 |
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