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Δγ(1)34.5 Herpes Simplex Viruses Encoding Human Cytomegalovirus IRS1 or TRS1 Induce Interferon Regulatory Factor 3 Phosphorylation and an Interferon-Stimulated Gene Response

The chimeric herpes simplex viruses (HSV) are Δγ(1)34.5 vectors encoding the human cytomegalovirus (HCMV) IRS1 or TRS1 genes. They are capable of late viral protein synthesis and are superior to Δγ(1)34.5 HSVs in oncolytic activity. The interferon (IFN) response limits efficient HSV gene expression...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
मुख्य लेखकों: Cassady, Kevin A., Saunders, Ute, Shimamura, Masako
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: American Society for Microbiology 2012
विषय:
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255867/
https://ncbi.nlm.nih.gov/pubmed/22072777
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05099-11
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