Molecular Determinants of Severe Acute Respiratory Syndrome Coronavirus Pathogenesis and Virulence in Young and Aged Mouse Models of Human Disease

SARS coronavirus (SARS-CoV) causes severe acute respiratory tract disease characterized by diffuse alveolar damage and hyaline membrane formation. This pathology often progresses to acute respiratory distress (such as acute respiratory distress syndrome [ARDS]) and atypical pneumonia in humans, with...

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Bibliographic Details
Main Authors: Frieman, Matthew, Yount, Boyd, Agnihothram, Sudhakar, Page, Carly, Donaldson, Eric, Roberts, Anjeanette, Vogel, Leatrice, Woodruff, Becky, Scorpio, Diana, Subbarao, Kanta, Baric, Ralph S.
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Pathogenesis and Immunity
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255850/
https://ncbi.nlm.nih.gov/pubmed/22072787
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05957-11
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