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Transmembrane Domain Determinants of CD4 Downregulation by HIV-1 Vpu

The transmembrane domains (TMDs) of integral membrane proteins do not merely function as membrane anchors but play active roles in many important biological processes. The downregulation of the CD4 coreceptor by the Vpu protein of HIV-1 is a prime example of a process that is dependent on specific p...

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Autors principals: Magadán, Javier G., Bonifacino, Juan S.
Format: Artigo
Idioma:Inglês
Publicat: American Society for Microbiology 2012
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Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255848/
https://ncbi.nlm.nih.gov/pubmed/22090097
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05933-11
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