The Virion-Associated Open Reading Frame 49 of Murine Gammaherpesvirus 68 Promotes Viral Replication both In Vitro and In Vivo as a Derepressor of RTA

Replication and transcription activator (RTA), an immediate-early gene, is a key molecular switch to evoke lytic replication of gammaherpesviruses. Open reading frame 49 (ORF49) is conserved among gammaherpesviruses and shown to cooperate with RTA in regulating virus lytic replication. Here we show...

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Bibliographic Details
Main Authors: Noh, Cheol-Woo, Cho, Hye-Jeong, Kang, Hye-Ri, Jin, Hyun Yong, Lee, Shaoying, Deng, Hongyu, Wu, Ting-Ting, Arumugaswami, Vaithilingaraja, Sun, Ren, Song, Moon Jung
Format: Artigo
Language:Inglês
Published: American Society for Microbiology 2012
Subjects:
Genome Replication and Regulation of Viral Gene Expression
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255801/
https://ncbi.nlm.nih.gov/pubmed/22090108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05785-11
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