The Virion-Associated Open Reading Frame 49 of Murine Gammaherpesvirus 68 Promotes Viral Replication both In Vitro and In Vivo as a Derepressor of RTA

Replication and transcription activator (RTA), an immediate-early gene, is a key molecular switch to evoke lytic replication of gammaherpesviruses. Open reading frame 49 (ORF49) is conserved among gammaherpesviruses and shown to cooperate with RTA in regulating virus lytic replication. Here we show...

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Autori principali: Noh, Cheol-Woo, Cho, Hye-Jeong, Kang, Hye-Ri, Jin, Hyun Yong, Lee, Shaoying, Deng, Hongyu, Wu, Ting-Ting, Arumugaswami, Vaithilingaraja, Sun, Ren, Song, Moon Jung
Natura: Artigo
Lingua:Inglês
Pubblicazione: American Society for Microbiology 2012
Soggetti:
Genome Replication and Regulation of Viral Gene Expression
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255801/
https://ncbi.nlm.nih.gov/pubmed/22090108
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.05785-11
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