Cisplatin Restores TRAIL apoptotic pathway in Glioblastoma-Derived Stem Cells through Up-regulation of DR5 and Down-regulation of c-FLIP

Glioblastoma-derived stem cells (GSCs) are responsible for the cancer resistance to therapies. We show here that GSC-enriched neurospheres are resistant to the treatment of tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) due to the insufficient expression of the death receptor DR4 an...

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Detalhes bibliográficos
Main Authors: Ding, Lijuan, Yuan, Changji, Wei, Feng, Wang, Guangyi, Zhang, Jing, Bellail, Anita C., Zhang, Zhaobin, Olson, Jeffrey J., Hao, Chunhai
Formato: Artigo
Idioma:Inglês
Publicado em: 2011
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255792/
https://ncbi.nlm.nih.gov/pubmed/21877938
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3109/07357907.2011.605412
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