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A multiparametric approach to monitor the effects of γ-secretase inhibition along the whole intestinal tract

γ-secretase inhibitors (GSIs) have been recently proposed as chemopreventive agents in gastrointestinal neoplasia, because they lead, through inhibition of the Notch signaling pathway, to goblet cell conversion in some intestinal adenomas of the Apc(Min) mice, and halt epithelial cell proliferation....

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Droy-Dupré, Laure, Vallée, Mickaël, Bossard, Céline, Laboisse, Christian L., Jarry, Anne
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: The Company of Biologists Limited 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255549/
https://ncbi.nlm.nih.gov/pubmed/21885452
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.007591
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