The mTOR inhibitor, everolimus (RAD001), overcomes resistance to imatinib in quiescent Ph-positive acute lymphoblastic leukemia cells

In Ph-positive (Ph(+)) leukemia, the quiescent cell state is one of the reasons for resistance to the BCR-ABL-kinase inhibitor, imatinib. In order to examine the mechanisms of resistance due to quiescence and the effect of the mammalian target of rapamycin inhibitor, everolimus, for such a resistant...

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Autori principali: Kuwatsuka, Y, Minami, M, Minami, Y, Sugimoto, K, Hayakawa, F, Miyata, Y, Abe, A, Goff, D J, Kiyoi, H, Naoe, T
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group 2011
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Original Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3255258/
https://ncbi.nlm.nih.gov/pubmed/22829152
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bcj.2011.16
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