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Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics
OBJECTIVES: The use of colistin in the treatment of life-threatening Gram-negative infections is associated with a high rate of nephrotoxicity that is dose limiting. This study aimed to examine the nephroprotective effect of ascorbic acid against colistin-induced nephrotoxicity. METHODS: Rats were t...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Oxford University Press
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3254197/ https://ncbi.nlm.nih.gov/pubmed/22127588 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr483 |
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