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Ascorbic acid protects against the nephrotoxicity and apoptosis caused by colistin and affects its pharmacokinetics

OBJECTIVES: The use of colistin in the treatment of life-threatening Gram-negative infections is associated with a high rate of nephrotoxicity that is dose limiting. This study aimed to examine the nephroprotective effect of ascorbic acid against colistin-induced nephrotoxicity. METHODS: Rats were t...

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Bibliographic Details
Main Authors: Yousef, Jumana M., Chen, Gong, Hill, Prue A., Nation, Roger L., Li, Jian
Format: Artigo
Language:Inglês
Published: Oxford University Press 2012
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3254197/
https://ncbi.nlm.nih.gov/pubmed/22127588
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/jac/dkr483
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