Sharpin Contributes to TNFα Dependent NFκB Activation and Anti-Apoptotic Signalling in Hepatocytes

TNFα stimulates both pro- and anti-apoptotic signalling in hepatocytes. Anti-apoptotic signalling depends on a cascade of ubiquitylation steps leading to NFκB activation. Using Sharpin-deficient mice, we show that the ubiquitin binding protein Sharpin interacts with Hoip, an E3 ligase which generate...

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Detalhes bibliográficos
Main Authors: Sieber, Sabrina, Lange, Nicole, Kollmorgen, Gwendlyn, Erhardt, Annette, Quaas, Alexander, Gontarewicz, Arthur, Sass, Gabriele, Tiegs, Gisa, Kreienkamp, Hans-Jürgen
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253811/
https://ncbi.nlm.nih.gov/pubmed/22253853
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029993
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