Chronic Administration of a Leupeptin-Derived Calpain Inhibitor Fails to Ameliorate Severe Muscle Pathology in a Canine Model of Duchenne Muscular Dystrophy

Calpains likely play a role in the pathogenesis of Duchenne muscular dystrophy (DMD). Accordingly, calpain inhibition may provide therapeutic benefit to DMD patients. In the present study, we sought to measure benefit from administration of a novel calpain inhibitor, C101, in a canine muscular dystr...

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Xehetasun bibliografikoak
Egile Nagusiak: Childers, Martin K., Bogan, Janet R., Bogan, Daniel J., Greiner, Hansel, Holder, Melanie, Grange, Robert W., Kornegay, Joe N.
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Research Foundation 2012
Gaiak:
Pharmacology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253583/
https://ncbi.nlm.nih.gov/pubmed/22291646
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fphar.2011.00089
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