Ubiquitin Homeostasis Is Critical for Synaptic Development and Function

The ubiquitin-proteasome system (UPS) controls protein abundance and is essential for many aspects of neuronal function. In ataxia (ax(J)) mice, profound neurological and synaptic defects result from a loss-of-function mutation in the proteasome-associated deubiquitinating enzyme Usp14, which is req...

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Autori principali: Chen, Ping-Chung, Bhattacharyya, Bula J., Hanna, John, Minkel, Heather, Wilson, Julie A., Finley, Daniel, Miller, Richard J., Wilson, Scott M.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Society for Neuroscience 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253363/
https://ncbi.nlm.nih.gov/pubmed/22131412
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1523/JNEUROSCI.2922-11.2011
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