The Cyclin Dependent Kinase Inhibitor p21 Is Essential for Resolution of Murine Inflammatory Arthritis via its C-Terminal Domain

OBJECTIVE: The mechanism responsible for persistent inflammation of the synovium that occurs in patients with rheumatoid arthritis (RA) is unknown. Previously, we were the first to demonstrate that expression of the cyclin dependent kinase (CDK) inhibitor p21((WAF1/CIP1)) is reduced in synovial tiss...

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Autori principali: Mavers, Melissa, Cuda, Carla M., Misharin, Alexander V., Gierut, Angelica K., Agrawal, Hemant, Weber, Evan, Novack, Deborah Veis, Haines, G. Kenneth, Balomenos, Dimitrios, Perlman, Harris
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2012
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253189/
https://ncbi.nlm.nih.gov/pubmed/21898359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/art.33311
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