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Metabolic Regulation of Invadopodia and Invasion by Acetyl-CoA Carboxylase 1 and De novo Lipogenesis

Invadopodia are membrane protrusions that facilitate matrix degradation and cellular invasion. Although lipids have been implicated in several aspects of invadopodia formation, the contributions of de novo fatty acid synthesis and lipogenesis have not been defined. Inhibition of acetyl-CoA carboxyla...

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Detalhes bibliográficos
Main Authors: Scott, Kristen E. N., Wheeler, Frances B., Davis, Amanda L., Thomas, Michael J., Ntambi, James M., Seals, Darren F., Kridel, Steven J.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2012
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253107/
https://ncbi.nlm.nih.gov/pubmed/22238651
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0029761
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