Specific involvement of atypical PKCζ/PKMζ in spinal persistent nociceptive processing following peripheral inflammation in rat

BACKGROUND: Central sensitization requires the activation of various intracellular signalling pathways within spinal dorsal horn neurons, leading to a lowering of activation threshold and enhanced responsiveness of these cells. Such plasticity contributes to the manifestation of chronic pain states...

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Main Authors: Marchand, Fabien, D'Mello, Richard, Yip, Ping K, Calvo, Margarita, Muller, Emilie, Pezet, Sophie, Dickenson, Anthony H, McMahon, Stephen B
Formato: Artigo
Idioma:Inglês
Publicado: BioMed Central 2011
Assuntos:
Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3253059/
https://ncbi.nlm.nih.gov/pubmed/22054645
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/1744-8069-7-86
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