Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

Early during Gram-negative sepsis, excessive release of pro-inflammatory cytokines can cause septic shock that is often followed by a state of immune paralysis characterized by the failure to mount adaptive immunity towards secondary microbial infections. Especially, the early mechanisms responsible...

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Κύριοι συγγραφείς: Schwandt, Timo, Schumak, Beatrix, Gielen, Gerrit H, Jüngerkes, Frank, Schmidbauer, Patricia, Klocke, Katrin, Staratschek-Jox, Andrea, van Rooijen, Niko, Kraal, Georg, Ludwig-Portugall, Isis, Franken, Lars, Wehner, Sven, Kalff, Jörg C, Weber, Olaf, Kirschning, Carsten, Coch, Christoph, Kalinke, Ulrich, Wenzel, Jörg, Kurts, Christian, Zawatzky, Rainer, Holzmann, Bernhard, Layland, Laura, Schultze, Joachim L, Burgdorf, Sven, den Haan, Joke MM, Knolle, Percy A, Limmer, Andreas
Μορφή: Artigo
Γλώσσα:Inglês
Έκδοση: Nature Publishing Group 2012
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Article
Διαθέσιμο Online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252580/
https://ncbi.nlm.nih.gov/pubmed/22036947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.380
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