Expression of type I interferon by splenic macrophages suppresses adaptive immunity during sepsis

Early during Gram-negative sepsis, excessive release of pro-inflammatory cytokines can cause septic shock that is often followed by a state of immune paralysis characterized by the failure to mount adaptive immunity towards secondary microbial infections. Especially, the early mechanisms responsible...

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Main Authors: Schwandt, Timo, Schumak, Beatrix, Gielen, Gerrit H, Jüngerkes, Frank, Schmidbauer, Patricia, Klocke, Katrin, Staratschek-Jox, Andrea, van Rooijen, Niko, Kraal, Georg, Ludwig-Portugall, Isis, Franken, Lars, Wehner, Sven, Kalff, Jörg C, Weber, Olaf, Kirschning, Carsten, Coch, Christoph, Kalinke, Ulrich, Wenzel, Jörg, Kurts, Christian, Zawatzky, Rainer, Holzmann, Bernhard, Layland, Laura, Schultze, Joachim L, Burgdorf, Sven, den Haan, Joke MM, Knolle, Percy A, Limmer, Andreas
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2012
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3252580/
https://ncbi.nlm.nih.gov/pubmed/22036947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/emboj.2011.380
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