Distinct association between aberrant methylation of Wnt inhibitors and genetic alterations in acute myeloid leukaemia

BACKGROUND: Aberrant activation of Wnt signalling through hypermethylation of Wnt inhibitor genes is involved in several human malignancies, including acute myeloid leukaemia (AML). It remains unclear whether hypermethylation of Wnt inhibitors is associated with molecular gene mutations in the devel...

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Detalhes bibliográficos
Main Authors: Hou, H-A, Kuo, Y-Y, Liu, C-Y, Lee, M C, Tang, J-L, Chen, C-Y, Chou, W-C, Huang, C-F, Lee, F-Y, Liu, M-C, Yao, M, Tien, H-F
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group 2011
Assuntos:
Genetics and Genomics
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251886/
https://ncbi.nlm.nih.gov/pubmed/22095226
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.471
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