Characterisation of the GRAF gene promoter and its methylation in patients with acute myeloid leukaemia and myelodysplastic syndrome

We report the isolation of the 5′ flanking region of GRAF (GTPase regulator associated with the focal adhesion kinase), previously described as a putative tumour suppressor gene of acute myelogenous leukaemia and myelodysplastic syndrome, and demonstrate its promoter activity in reporter gene assays...

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Détails bibliographiques
Auteurs principaux: Bojesen, S E, Ammerpohl, O, Weinhäusl, A, Haas, O A, Mettal, H, Bohle, R M, Borkhardt, A, Fuchs, U
Format: Artigo
Langue:Inglês
Publié: Nature Publishing Group 2006
Sujets:
Genetics and Genomics
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC2361128/
https://ncbi.nlm.nih.gov/pubmed/16404424
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/sj.bjc.6602939
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