Overexpression of microRNA-223 regulates the ubiquitin ligase FBXW7 in oesophageal squamous cell carcinoma

BACKGROUND: F-box and WD repeat domain-containing 7 (FBXW7) is a cell cycle regulatory gene whose protein product ubiquitinates positive cell cycle regulators such as c-Myc, cyclin E, and c-Jun, thereby acting as a tumour-suppressor gene. This study focused on microRNA-223 (miR-223), which is a cand...

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Hlavní autoři: Kurashige, J, Watanabe, M, Iwatsuki, M, Kinoshita, K, Saito, S, Hiyoshi, Y, Kamohara, H, Baba, Y, Mimori, K, Baba, H
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group 2012
Témata:
Molecular Diagnostics
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251856/
https://ncbi.nlm.nih.gov/pubmed/22108521
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/bjc.2011.509
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