MHC Class I negatively regulates synapse density during the establishment of cortical connections

Major histocompatibility complex class I (MHCI) molecules modulate activity-dependent refinement and plasticity. Here, we show that MHCI also negatively regulates the density and function of cortical synapses during their initial establishment both in vitro and in vivo. MHCI molecules are expressed...

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Hauptverfasser: Glynn, Marian W., Elmer, Bradford M., Garay, Paula A., Liu, Xiao-Bo, Needleman, Leigh A., El-Sabeawy, Faten, McAllister, A. Kimberley
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2011
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251641/
https://ncbi.nlm.nih.gov/pubmed/21358642
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/nn.2764
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