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Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice

Collecting duct (CD) adenylyl cyclase VI (AC6) has been implicated in arginine vasopressin (AVP)-stimulated renal water reabsorption. To evaluate the role of CD-derived AC6 in regulating water homeostasis, mice were generated with CD-specific knockout (KO) of AC6 using the Cre/loxP system. CD AC6 KO...

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Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Prif Awduron: Roos, Karl P., Strait, Kevin A., Raphael, Kalani L., Blount, Mitsi A., Kohan, Donald E.
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: American Physiological Society 2012
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251343/
https://ncbi.nlm.nih.gov/pubmed/21937603
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00397.2011
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