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Collecting duct-specific knockout of adenylyl cyclase type VI causes a urinary concentration defect in mice
Collecting duct (CD) adenylyl cyclase VI (AC6) has been implicated in arginine vasopressin (AVP)-stimulated renal water reabsorption. To evaluate the role of CD-derived AC6 in regulating water homeostasis, mice were generated with CD-specific knockout (KO) of AC6 using the Cre/loxP system. CD AC6 KO...
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| Main Authors: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
American Physiological Society
2012
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3251343/ https://ncbi.nlm.nih.gov/pubmed/21937603 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1152/ajprenal.00397.2011 |
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