Specificity of Human Aldo-Keto Reductases, NAD(P)H: Quinone Oxidoreductase and Carbonyl Reductases to Redox-Cycle Polycyclic Aromatic Hydrocarbon Diones and 4-Hydroxyequilenin-o-Quinone

Polycyclic aromatic hydrocarbons (PAH) are suspect human lung carcinogens and can be metabolically activated to remote quinones, e.g. benzo[a]pyrene-1,6-dione (B[a]P-1,6-dione) and B[a]P-3,6-dione by the action of either P450 monooxygenase or peroxidases and to non-K region o-quinones by aldo-keto r...

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Detaylı Bibliyografya
Asıl Yazarlar: Shultz, Carol A., Quinn, Amy M., Park, Jong-Heum, Harvey, Ronald G., Bolton, Judy L, Maser, Edmund, Penning, Trevor M.
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: 2011
Konular:
Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251162/
https://ncbi.nlm.nih.gov/pubmed/21910479
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/tx200294c
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