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Rational design of an evolutionary precursor of glutaminyl-tRNA synthetase

The specificity of most aminoacyl-tRNA synthetases for an amino acid and cognate tRNA pair evolved before the divergence of the three domains of life. Glutaminyl-tRNA synthetase (GlnRS) evolved later and is derived from the archaeal-type nondiscriminating glutamyl-tRNA synthetase (GluRS), an enzyme...

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Bibliografske podrobnosti
Main Authors: O’Donoghue, Patrick, Sheppard, Kelly, Nureki, Osamu, Söll, Dieter
Format: Artigo
Jezik:Inglês
Izdano: National Academy of Sciences 2011
Teme:
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251134/
https://ncbi.nlm.nih.gov/pubmed/22158897
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1117294108
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