RNAi-mediated knockdown of Xist can rescue the impaired postimplantation development of cloned mouse embryos

Cloning mammals by somatic cell nuclear transfer (SCNT) is highly inefficient. Most SCNT-generated embryos die after implantation because of unidentified, complex epigenetic errors in the process of postimplantation embryonic development. Here we identify the most upstream level of dysfunction leadi...

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Autori principali: Matoba, Shogo, Inoue, Kimiko, Kohda, Takashi, Sugimoto, Michihiko, Mizutani, Eiji, Ogonuki, Narumi, Nakamura, Toshinobu, Abe, Kuniya, Nakano, Toru, Ishino, Fumitoshi, Ogura, Atsuo
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
Soggetti:
Biological Sciences
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3251083/
https://ncbi.nlm.nih.gov/pubmed/22065773
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1112664108
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