Fibronectin III 13-14 Domains Induce Joint Damage via Toll-Like Receptor 4 Activation and Synergize with Interleukin-1 and Tumour Necrosis Factor

Cartilage loss is a feature of chronic arthritis. It results from degradation of the extracellular matrix which is composed predominantly of aggrecan and type II collagen. Extracellular matrix degradation is mediated by aggrecanases and matrix metalloproteinases (MMPs). Recently, a number of endogen...

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Bibliographic Details
Main Authors: Sofat, Nidhi, Robertson, Saralili Dipa, Wait, Robin
Format: Artigo
Language:Inglês
Published: S. Karger AG 2011
Subjects:
Research Article
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250657/
https://ncbi.nlm.nih.gov/pubmed/21997473
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1159/000329632
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