Intraocular Safety and Pharmacokinetics of Hexadecyloxypropyl-Cidofovir (HDP-CDV) as a Long-lasting Intravitreal Antiviral Drug

PURPOSE. To evaluate the intraocular safety and pharmacokinetics of hexadecyloxypropyl-cidofovir (HDP-CDV), the hydrolysis product of HDP-cyclic-CDV, a long-lasting intravitreal cidofovir prodrug for cytomegalovirus (CMV) retinitis. METHODS. HDP-cyclic-CDV was suspended in phosphate-buffered saline...

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Main Authors: Wang, Haiyan, Chhablani, Jay, Freeman, William R., Beadle, James R., Hostetler, Karl Y., Hartmann, Kathrin, Conner, Laura, Aldern, Kathy A., Pearson, Lindsey, Cheng, Lingyun
Formato: Artigo
Idioma:Inglês
Publicado: Association for Research in Vision and Ophthalmology, Inc. 2011
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Articles
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250264/
https://ncbi.nlm.nih.gov/pubmed/22058340
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.11-8293
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