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PRDM1 is a tumor suppressor gene in natural killer cell malignancies

Natural killer cell lymphoma (NKCL) constitutes a rare and aggressive form of non-Hodgkin lymphoma, and there is little insight into its pathogenesis. Here we show that PRDM1 is a tumor suppressor gene in NKCLs that is inactivated by a combination of monoallelic deletion and promoter CpG island hype...

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Autori principali: Küçük, Can, Iqbal, Javeed, Hu, Xiaozhou, Gaulard, Phillip, De Leval, Laurence, Srivastava, Gopesh, Au, Wing Yan, McKeithan, Timothy W., Chan, Wing C.
Natura: Artigo
Lingua:Inglês
Pubblicazione: National Academy of Sciences 2011
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250125/
https://ncbi.nlm.nih.gov/pubmed/22143801
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1115128108
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