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Mechanism of inhibition of connexin channels by the quinine derivative N-benzylquininium
The anti-malarial drug quinine and its quaternary derivative N-benzylquininium (BQ(+)) have been shown to inhibit gap junction (GJ) channels with specificity for Cx50 over its closely related homologue Cx46. Here, we examined the mechanism of BQ(+) action using undocked Cx46 and Cx50 hemichannels, w...
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| Main Authors: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
The Rockefeller University Press
2012
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3250100/ https://ncbi.nlm.nih.gov/pubmed/22200948 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1085/jgp.201110678 |
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