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Loop Gating of Connexin Hemichannels Involves Movement of Pore-lining Residues in the First Extracellular Loop Domain

Unapposed connexin hemichannels exhibit robust closure in response to membrane hyperpolarization and extracellular calcium. This form of gating, termed “loop gating,” is largely responsible for regulating hemichannel opening, thereby preventing cell damage through excessive flux of ions and metaboli...

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Detalhes bibliográficos
Main Authors: Verselis, Vytas K., Trelles, Maria P., Rubinos, Clio, Bargiello, Thaddeus A., Srinivas, Miduturu
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2009
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640974/
https://ncbi.nlm.nih.gov/pubmed/19074140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807430200
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