Loop Gating of Connexin Hemichannels Involves Movement of Pore-lining Residues in the First Extracellular Loop Domain

Unapposed connexin hemichannels exhibit robust closure in response to membrane hyperpolarization and extracellular calcium. This form of gating, termed “loop gating,” is largely responsible for regulating hemichannel opening, thereby preventing cell damage through excessive flux of ions and metaboli...

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Bibliographic Details
Main Authors: Verselis, Vytas K., Trelles, Maria P., Rubinos, Clio, Bargiello, Thaddeus A., Srinivas, Miduturu
Format: Artigo
Language:Inglês
Published: American Society for Biochemistry and Molecular Biology 2009
Subjects:
Membrane Transport, Structure, Function, and Biogenesis
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC2640974/
https://ncbi.nlm.nih.gov/pubmed/19074140
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.M807430200
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