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Prediction of Relative In Vivo Metabolite Exposure from In Vitro Data Using Two Model Drugs: Dextromethorphan and Omeprazole

Metabolites can have pharmacological or toxicological effects, inhibit metabolic enzymes, and be used as probes of drug-drug interactions or specific cytochrome P450 (P450) phenotypes. Thus, better understanding and prediction methods are needed to characterize metabolite exposures in vivo. This stu...

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Библиографические подробности
Главные авторы: Lutz, Justin D., Isoherranen, Nina
Формат: Artigo
Язык:Inglês
Опубликовано: The American Society for Pharmacology and Experimental Therapeutics 2012
Предметы:
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3250047/
https://ncbi.nlm.nih.gov/pubmed/22010218
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1124/dmd.111.042200
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