Piperidine Acetic Acid Based γ-Secretase Modulators Directly Bind to Presenilin-1

[Image: see text] Aβ42 is believed to play a causative role in Alzheimer’s disease (AD) pathogenesis. γ-Secretase modulators (GSMs) are actively being pursued as potential AD therapeutics because they selectively alter the cleavage site of the amyloid precursor protein (APP) to reduce the formation...

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Bibliographische Detailangaben
Hauptverfasser: Crump, Christina J., Fish, Benjamin A., Castro, Suita V., Chau, De-Ming, Gertsik, Natalya, Ahn, Kwangwook, Stiff, Cory, Pozdnyakov, Nikolay, Bales, Kelly R., Johnson, Douglas S., Li, Yue-Ming
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Chemical Society 2011
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249837/
https://ncbi.nlm.nih.gov/pubmed/22229075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1021/cn200098p
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