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Protection from Palmitate-Induced Mitochondrial DNA Damage Prevents from Mitochondrial Oxidative Stress, Mitochondrial Dysfunction, Apoptosis, and Impaired Insulin Signaling in Rat L6 Skeletal Muscle Cells

Saturated free fatty acids have been implicated in the increase of oxidative stress, mitochondrial dysfunction, apoptosis, and insulin resistance seen in type 2 diabetes. The purpose of this study was to determine whether palmitate-induced mitochondrial DNA (mtDNA) damage contributed to increased ox...

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Главные авторы: Yuzefovych, Larysa V., Solodushko, Viktoriya A., Wilson, Glenn L., Rachek, Lyudmila I.
Формат: Artigo
Язык:Inglês
Опубликовано: Endocrine Society 2012
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Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249685/
https://ncbi.nlm.nih.gov/pubmed/22128025
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1210/en.2011-1442
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