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Mitochondrial DNA Damage and Dysfunction, and Oxidative Stress Are Associated with Endoplasmic Reticulum Stress, Protein Degradation and Apoptosis in High Fat Diet-Induced Insulin Resistance Mice
BACKGROUND: Recent studies showed a link between a high fat diet (HFD)-induced obesity and lipid accumulation in non-adipose tissues, such as skeletal muscle and liver, and insulin resistance (IR). Although the mechanisms responsible for IR in those tissues are different, oxidative stress and mitoch...
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Main Authors: | , , , |
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Formato: | Artigo |
Idioma: | Inglês |
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Public Library of Science
2013
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Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC3546973/ https://ncbi.nlm.nih.gov/pubmed/23342074 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0054059 |
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