Genomic instability induced by mutant succinate dehydrogenase subunit D (SDHD) is mediated by O(2)(−•) and H(2)O(2)

SDHD mutations are associated with human cancers but the mechanisms that may contribute to transformation are unknown. The hypothesis that mutations in SDHD increase levels of superoxide leading to genomic instability was tested using site-directed mutagenesis to generate a truncated SDHD cDNA that...

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Main Authors: Owens, Kjerstin M., Aykin-Burns, Nōkhet, Dayal, Disha, Coleman, Mitchell C., Domann, Frederick E., Spitz, Douglas R.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Article
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249516/
https://ncbi.nlm.nih.gov/pubmed/22041456
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.freeradbiomed.2011.10.435
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