Instability of Succinate Dehydrogenase in SDHD Polymorphism Connects Reactive Oxygen Species Production to Nuclear and Mitochondrial Genomic Mutations in Yeast

Aims: Mitochondrial succinate dehydrogenase (SDH) is an essential complex of the electron transport chain and tricarboxylic acid cycle. Mutations in the human SDH subunit D frequently lead to paraganglioma (PGL), but the mechanistic consequences of the majority of SDHD polymorphisms have yet to be u...

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Enregistré dans:
Détails bibliographiques
Publié dans:Antioxid Redox Signal
Auteurs principaux: Chang, Ya-Lan, Hsieh, Meng-Hsun, Chang, Wei-Wen, Wang, Hurng-Yi, Lin, Mei-Chun, Wang, Cheng-Ping, Lou, Pei-Jen, Teng, Shu-Chun
Format: Artigo
Langue:Inglês
Publié: Mary Ann Liebert, Inc. 2015
Sujets:
Original Research Communications
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC4334101/
https://ncbi.nlm.nih.gov/pubmed/25328978
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1089/ars.2014.5966
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