Donor pre-treatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model

Depletion of the nitric oxide synthase cofactor tetrahydrobiopterin (H4B) during ischemia and reperfusion is associated with severe graft pancreatitis. Since clinically feasible approaches to prevent ischemia reperfusion injury (IRI) by H4B-substitution are missing we investigated its therapeutic po...

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Autores principales: Maglione, M, Oberhuber, R, Cardini, B, Watschinger, K, Hermann, M, Obrist, P, Hengster, P, Mark, W, Schneeberger, S, Werner-Felmayer, G, Pratschke, J, Margreiter, R, Werner, ER, Brandacher, G
Formato: Artigo
Lenguaje:Inglês
Publicado: 2010
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249459/
https://ncbi.nlm.nih.gov/pubmed/20883557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2010.03262.x
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