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Donor pre-treatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model

Depletion of the nitric oxide synthase cofactor tetrahydrobiopterin (H4B) during ischemia and reperfusion is associated with severe graft pancreatitis. Since clinically feasible approaches to prevent ischemia reperfusion injury (IRI) by H4B-substitution are missing we investigated its therapeutic po...

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Detalhes bibliográficos
Main Authors: Maglione, M, Oberhuber, R, Cardini, B, Watschinger, K, Hermann, M, Obrist, P, Hengster, P, Mark, W, Schneeberger, S, Werner-Felmayer, G, Pratschke, J, Margreiter, R, Werner, ER, Brandacher, G
Formato: Artigo
Idioma:Inglês
Publicado em: 2010
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Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249459/
https://ncbi.nlm.nih.gov/pubmed/20883557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2010.03262.x
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