Donor pre-treatment with tetrahydrobiopterin saves pancreatic isografts from ischemia reperfusion injury in a mouse model

Depletion of the nitric oxide synthase cofactor tetrahydrobiopterin (H4B) during ischemia and reperfusion is associated with severe graft pancreatitis. Since clinically feasible approaches to prevent ischemia reperfusion injury (IRI) by H4B-substitution are missing we investigated its therapeutic po...

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Autors principals: Maglione, M, Oberhuber, R, Cardini, B, Watschinger, K, Hermann, M, Obrist, P, Hengster, P, Mark, W, Schneeberger, S, Werner-Felmayer, G, Pratschke, J, Margreiter, R, Werner, ER, Brandacher, G
Format: Artigo
Idioma:Inglês
Publicat: 2010
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249459/
https://ncbi.nlm.nih.gov/pubmed/20883557
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1600-6143.2010.03262.x
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