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Mechanism of translocation of uracil-DNA glycosylase from Escherichia coli between distributed lesions

Uracil-DNA glycosylase (Ung) is a DNA repair enzyme that excises uracil bases from DNA, where they appear through deamination of cytosine or incorporation from a cellular dUTP pool. DNA repair enzymes often use one-dimensional diffusion along DNA to accelerate target search; however, this mechanism...

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Main Authors: Mechetin, Grigory V., Zharkov, Dmitry O.
Formato: Artigo
Idioma:Inglês
Publicado: 2011
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Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC3249333/
https://ncbi.nlm.nih.gov/pubmed/21971549
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbrc.2011.09.106
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